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PhD student in Biochemistry @ UNIVERSITY OF STOCKHOLM , SWEDEN

PhD student in Biochemistry

at the Department of Biochemistry and Biophysics. Closing date: 24 September, 2019.

The Department of Biochemistry and Biophysics is mainly located in the Arrhenius Laboratories, which are situated at the University Campus at Frescati. Presently more than 250 people are working at the department, of which around 100 are PhD students, engaged in internationally highly recognized research. The research projects span across a broad range of topics covering various aspects of structure and function of biological systems. The combination of the highly interdisciplinary expertise and research projects at the department is unique in Sweden and also at an international level. This expertise ranges across cell biology, biochemistry, biophysics, neurochemistry and theory. The Science for Life Laboratory is also closely linked to the department.

Project description
Your studies in Biochemistry will be in the project: “Structural dynamics and allosteric regulation of sodium/proton exchangers”.

Solute carrier (SLC) transporters are the targets for many drugs and they often play a major role in drug pharmacokinetics. Understanding the mechanisms by which SLC transporters shuttle and move ions, drugs, and natural compounds across membranes is of fundamental importance. Because of the technical difficulties in working with SLC transporters our mechanistic understanding has been hampered. The goal of our research is to establish transporter mechanisms of SLC transporters using a combination of X-ray crystallography, single-particle cryo EM, biophysical and biochemical techniques.

We have 2 ERC Consolidator (EXCHANGE) funded PhD positions available, which will focus on dissecting the structure, dynamics, and allosteric regulation of sodium/proton exchangers, from the SLC family. This is a multidisciplinary project and the successful candidate should have a M.Sc. in biology, biophysics or biochemistry. Experience in biophysics and cell biology is not a prerequisite but an advantage.

We seek a biochemist/structural biologist interested in serial crystallography and micro ED methods, to capture important structural intermediate steps of sodium/proton exchangers. You will be expected to work with PostDoc to determine single-particle cryo EM structures of these complexes. The student will be expected to carry out population dynamics of sodium/proton exchangers and develop high-throughput assays to establish interactions with drugs, lipids and new inhibitors.

Please include a short motivation, your CV (plus diplomas and certificates/date when you expect to finish your studies), and the contact details of at least two references in your application.

Relevant publication from our lab:

Nature (2011) 478:408-11: NHE fold same as sodium-coupled bile acid transporters; Nature (2013) 501:573: Outward-facing structure of NapA from T. thermophilus; JGP (2014) 529-44: Dimeric crystal structure of E. coli NhaA; Nat. Struct. Mol. Biol. (2016) 3:248: Elevator mechanism of Na+/H+ exchange;
PNAS (2017) 114(7): Proton coupling in Na+/H+ exchangers NapA and human NHA2; Nature Comms (2017) 8:13993: Lipids interactions in Na+/H+ exchangers; Nature (2017) 421-424; Lipids dependence associated with dimerization (NapA vs. NhaA); Nature Comms (2018): Lipids in NhaA dimerization

Qualification requirements
In order to meet the general entry requirements, the applicant must have completed a second-cycle degree, completed courses equivalent to at least 240 higher education credits, of which 60 credits must be in the second cycle, or have otherwise acquired equivalent knowledge in Sweden or elsewhere.

In order to meet the specific entry requirements, for acceptance in the Biochemistry program the applicant must have passed courses within the first and second cycles of at least 120 credits in Biochemistry/Life Science, including at least 15 credits Biochemistry at the second cycle level and a Degree Project (thesis) also in Biochemistry of 30 credits.

The qualification requirements must be met by the deadline for applications.

Selection
The selection among the eligible candidates will be based on their capacity to successfully complete the program. Important criteria when assessing this capacity are; documented knowledge and skill in the field of the thesis project, written and oral proficiency in English, the capacity for analytical thinking, the ability to collaborate, as well as creativity, initiative, and independence. The assessment will be based on previous experience and grades, the quality of the degree project, references, relevant experience, interviews and the candidate’s written motivation for seeking the position.

Admission Regulations for Doctoral Studies at Stockholm University are available at: www.su.se/rules and regulations.

Terms of employment
Only a person who will be or has already been admitted to a third-cycle programme may be appointed to a doctoral studentship.

The term of the initial contract may not exceed one year. The employment may be extended for a maximum of two years at a time. However, the total period of employment may not exceed the equivalent of four years of full-time study.

Doctoral students should primarily devote themselves to their own education, but may engage in teaching, research, and administration corresponding to a maximum of 20 % of a full-time position.

Please note that admission decisions cannot be appealed.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact
For more information, please contact the Project Leader, Professor David Drew, david.drew@dbb.su.se.

General information about the PhD programs can be given by the Director of Doctoral Studies, Pia Ädelroth, pia.adelroth@dbb.su.se, or the Head of the Department, Lena Mäler, lenam@dbb.su.se.

Union representatives

Ingrid Lander (Saco-S), tfn 0708-16 26 64, saco@saco.su.se, Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), tfn 08-16 34 89, alejandra@st.su.se, samt seko@seko.su.se (SEKO).

Application
Apply for the PhD student position at Stockholm University’s recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

Please include the following information with your application

  • Your contact details and personal data
  • Your highest degree
  • Your language skills
  • Contact details for 2–3 references

and, in addition, please include the following documents

  • Cover letter
  • CV – degrees and other completed courses, work experience and a list of degree projects/theses
  • Research proposal (no more than 3 pages) describing:
    – why you are interested in the field/project described in the advertisement
    – why and how you wish to complete the project
    – what makes you suitable for the project in question
  • Degree certificates and grades confirming that you meet the general and specific entry requirements (no more than 6 files)
  • Letters of recommendation (no more than 6 files)
  • Degree projects/theses (no more than 6 files).

The instructions for applicants are available at: Instructions – Applicants.

You are welcome to apply!

Stockholm University – our education and research produce results.

Closing date: 24/09/2019

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